Phospho-acss2
WebDownload scientific diagram Targeting OGT or CDKs blocks GBM growth ex vivo a Representative images depicting tumor growth in organotypic brain slices derived from mice intracranially injected ... WebNational Center for Biotechnology Information
Phospho-acss2
Did you know?
WebNov 23, 2024 · ACSS2 enables cholesterol synthesis in the cytoplasm, which is trafficked to the surface to provide mechanical tenacity. GM3-IRE1-sXBP1-ACSS2-cholesterol axis is … WebMay 25, 2024 · In the nucleus, ACSS2 binds to transcription factor EB and translocates to lysosomal and autophagy gene promoter regions, where ACSS2 incorporates acetate generated from histone acetylation turnover to locally produce acetyl-CoA for histone H3 acetylation in these regions and promote lysosomal biogenesis, autophagy, cell survival, …
WebDownload scientific diagram Cdk5 and p35 are important for proliferation of human TT cells. A, lysates of TT cells were immunoblotted by specific antibodies of Cdk5 and p35 with variant loading ... WebProduct Name ACSS2(Phospho-Ser659) Antibody; Host Species Rabbit; Clonality Polyclonal; Isotype IgG; Applications WB; Species Reactivity Hu Ms; Immunogen Description The …
WebNov 12, 2024 · ACSS2 is the only known enzyme that can recycle acetate derived from deacetylation reactions in the cytoplasm and nucleus of cells, including both protein and metabolite deacetylation reactions. As such, ACSS2 can recycle acetate derived from histone deacetylase reactions as well as protein deacetylation reactions mediated by … WebAug 26, 2016 · ACSS2 is highly upregulated in multiple cancer types and may be a useful biomarker for anti-ACSS2 therapies. [ 11 C]acetate has demonstrated excellent potential as an alternative positron emission ...
WebJun 1, 2024 · ACSS2 is phosphorylated at Ser659 by AMPK and then forms a translocation complex with Importin α5 to translocate into the nucleus. This process interacts with TFEB, resulting in upregulated...
WebJan 21, 2024 · We interrogate whether ACSS2 can facilitate the local transfer of acetyl groups. Our results point to direct transfer of intact acetate that is mediated by ACSS2, underscoring a critical function of acetate transfer in using local and nuclear acetate pools for histone acetylation and rapid transcriptional activation. how to tell if your phone is infectedWebSep 15, 2024 · The invention relates to novel compositions, combinations and methods relating to compounds which inhibit EZH2 and their uses for treating and/or preventing tumors associated with methyltransferase EZH2. More specifically the invention relates to synergistic bi-therapy compositions for use in a method of treating and/or preventing … real estate mls pinellas county floridaWebMay 31, 2024 · A decrease in ACSS2 lowers nuclear acetyl-CoA levels, histone acetylation, and responsive expression of the cohort of neuronal genes. In adult mice, attenuation of hippocampal ACSS2 expression ... how to tell if your home has termitesWebJul 7, 2024 · ACSS2 has been found to primarily undergo translocation from the cytoplasm to the nucleus . ACSS2 translocation is tightly connected with hormonal and transcription … real estate offer deadlineWebJul 7, 2024 · Acetyl-CoA synthetase 2 (ACSS2) is a crucial member of the acetyl-CoA synthetase (ACSS) family and is transcribed from the ACSS2 gene. The ACSS2 gene, first isolated from yeast cells, encodes two isoforms produced by alternative transcription start site selection, with lengths of 1606 bp and 2106 bp [ 8 ]. how to tell if your iphone is being trackedWebMay 31, 2024 · ACSS2 seems to bind to the promoters of immediate early genes before memory consolidation, implying that acetate, rather than ACSS2, is the limiting factor for histone acetylation at these genes. how to tell if your phone is being tappedWebJun 11, 2024 · Abstract. Autophagy is an intracellular degenerative pathway which is responsible for neuronal survival. Under the condition of nutrient deprivation, autophagy can lead to dysfunction in memory consolidation. … how to tell if your body has too much pepsin