Imp-1/crd-bp function
Witryna9 kwi 2024 · CRD-BP has a dominant role in proliferation of human K562 cells by an IGF-II-dependent mechanism independent of its ability to serve as a c-myc … Witrynaprotein. CRD-BP was later shown to be identical to IMP-1 (14, 19). CRD-BP/IMP-1 is highly related to IMP-2 and IMP-3, which together comprise a family of proteins that …
Imp-1/crd-bp function
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Witryna18 maj 2010 · Molecular Function: translation regulator activity Source:BHF-UCL. 1 publication. ... IMP-1; IMP1. Alternative names. Coding region determinant-binding … WitrynaIGF2BP1. Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene. [5] [6] [7] This gene encodes a member of the IGF …
Witryna25 maj 2007 · CRD-BP/IMP-1 expression in HCT116 colon cancer cells (a) and adult human colon (b–e).Immunohistochemistry was performed as described in the Material and methods section by either using a rabbit anti-CRD-BP/IMP1 antibody (a and e), or by using a goat anti CRD-BP/IMP-1 antibody (b–d).In normal mucosa (b, d, e) CRD … Witryna29 sie 2024 · Introduction. Insulin-like growth factor II mRNA-binding protein 1 (IGF2BP1/IMP1), also known as the c-Myc coding region determinant-binding protein (CRD-BP) and zipcode-binding protein 1 (ZBP1), is a multifunctional RNA-binding protein that binds to diverse cancer-associated mRNAs to promote mRNA stability, …
WitrynaMouse coding region determinant–binding (mCRD‐BP) and human IGF‐II mRNA–binding 1 (hIMP‐1) proteins are orthologous mRNA‐binding proteins that recognize c‐myc and IGF‐II mRNA, respectively, and regul... Witryna9 paź 2013 · High levels of CRD-BP that are found in primary human colorectal tumours exhibiting active beta-catenin/Tcf signalling implicates CRD-BP induction in the upregulation of beta TrCP1, in the ...
Witryna19 lis 2004 · CRD-BP/IMP-1 is highly related to IMP-2 and IMP-3, which together comprise a family of proteins that bind to the 5′-untranslated region of IGF-II leader 3 mRNA. ... In summary, our results revealed a novel function for CRD-BP in cell proliferation involving an IGF-II-dependent mechanism that appears independent of …
The mouse Coding Region Determinant-Binding Protein (CRD-BP) is an RNA-binding protein. CRD-BP belongs to a family of RNA binding proteins that show close a relation to the chicken β-actin zipcode-binding protein ZBP1 and the human forms of the protein IMP-1, IMP-2 and IMP-3. Because of their close … Zobacz więcej CRD-BP is a 577 amino acid protein that contains 4 KH domains, 2 RRMs and a RGG box (Figure 2). CRD-BP and human IMP-1 are not identical but shows a high degree of resemblance. They are very closely related … Zobacz więcej CRD-BP and its orthologs have been shown to have the ability to bind CD44, beta-actin, c-myc, IGF2, H19 and tau RNA transcripts. CRD-BP has been shown to play a crucial role in cancer growth and invasion of tissues. CD44 proteins belong to a family of … Zobacz więcej highland park tower st paulWitryna15 cze 2006 · CRD-BP function seems to be important for the pathogenesis of human colorectal ... P. et al. C-MYC and IGF-II mRNA-binding protein (CRD-BP/IMP-1) in benign and malignant mesenchymal tumors. Int. ... highland park trails gaWitryna31 sty 2007 · CRD-BP protects the c-myc CRD and MDR-1 RNA from cleavage by the mammalian endoribonuclease. Having established that recombinant CRD-BP can bind c-myc CRD and MDR-1 RNA, we then sought to determine if the binding of CRD-BP to RNA could directly protect these transcripts from degradation by an endoribonuclease … highland park tree lightingWitryna1 paź 2010 · Europe PMC is an archive of life sciences journal literature. Introduction. CRD-BP, the coding region determinant binding protein, also known as insulin-like growth factor 2 mRNA-binding protein 1 (IMP-1 or IGF2BP-1), is a multifunctional RNA binding protein involved in different processes such as mRNA turnover, translation control, … how is joe biden polling todayWitryna7 sty 2011 · CRD-BP was shown to upregulate the expression of different genes including c-myc, 13 β-TrCP1, 10 MDR1, 14 and GLI1. 15 It was also shown to be necessary for proper cell adhesion, cytoplasmic spreading, and invadopodia formation through its binding to the 3′UTR of CD44 mRNA and stabilization of the mRNA. In … how is joey chestnut able to eat so muchWitrynaCRD-BP belongs to a family of RNA binding proteins that show close a relation to the chicken β-actin zipcode-binding protein ZBP1[1] and the human forms of the protein … how is joe burrowWitrynaHere, we confirm that human CRD-BP/IMP-1 binds to c-myc mRNA and that it is predominantly expressed in fetal tissues. Moreover, hCRD-BP/IMP-1 expression was detected in cell lines of neoplastic origin and in selected primary tumors. In a series of 33 malignant and 10 benign mesenchymal tumors, 73% and 40%, respectively, were … highland park trick or treat 2022