Fth and ferroptosis

Author: etkh

August undefined, 2024

WebFerroptosis, a novel type of cell-regulated death caused by iron-dependent lipid peroxidation, has been implicated in a variety of pathophysiological processes and is a potential therapeutic target for the treatment of many diseases. 2 Accumulating evidence suggests that ferroptosis is crucially involved in the mechanism for cell death occurred ... WebNov 18, 2024 · Taken together, these data indicate that melatonin produces cerebroprotection, at least partly by inhibiting neuronal Fth-mediated ferroptosis following TBI, supporting the notion that melatonin is an excellent ferroptosis inhibitor and its anti-ferroptosis provides a potential therapeutic target for treating TBI.

Ferroptosis as a novel therapeutic target for cardiovascular disease

WebFeb 3, 2024 · To investigate ferroptosis involved in HHP-induced VSMC novel phenotypes, we measured the GPX4 (a key enzyme of ferroptosis) protein level. Here, we showed … WebFerroptosis, a new non-necrotizing programmed cell death (PCD), is driven by iron-dependent phospholipid peroxidation. Ferroptosis plays a key role in secondary … heimo nuutinen

Amentoflavone suppresses cell proliferation and induces cell …

WebMar 16, 2024 · Ferroptosis and iron-related redox imbalance aggravate traumatic brain injury (TBI) outcomes. NRF2 is the predominant transcription factor regulating oxidative stress and neuroinflammation in TBI, but its role in iron-induced post-TBI damage is unclear. We investigated ferroptotic neuronal damage in the injured cortex and observed … Web1 day ago · Ferroptosis transcriptomics research for tumor treatment is the forefront of current research [6]. However, few studies have linked machine deep learning with tumor … WebSep 1, 2024 · One can speculate that the increase of FTH under hypoxia protects HT1080 cells from ferroptosis. The increase of FTH and FTMT by RSL-3, which was … heimo nuutinen 2023

Cells Free Full-Text Ferroptosis Meets Cell–Cell Contacts

Quercetin Ameliorates Diabetic Kidney Injury by Inhibiting Ferroptosis …

WebNational Center for Biotechnology Information WebSep 17, 2024 · Exposure to the intestinal I/R injury increased the expression of Ptgs2 mRNA (p < 0.01, Figure 6D) and decreased the expression of Gpx4 (p < 0.05, Figure 6E and F) … heimo roselli messerWebApr 3, 2024 · Ferroptosis is an iron-dependent cell death pathway that is different from apoptosis, pyroptosis, and necrosis. The main characteristics of ferroptosis are the Fenton reaction mediated by intracellular free divalent iron ions, lipid peroxidation of cell membrane lipids, and inhibition of the anti-lipid peroxidation activity of intracellular glutathione … heimo rainer nhm

"WebMay 6, 2024 · Ferroptosis is an iron-dependent form of oxidative cell death, and the inhibition of ferroptosis is a promising strategy with which to prevent and treat … " - Fth and ferroptosis

Fth and ferroptosis

FTH promotes the proliferation and renders the HCC cells …

WebMar 29, 2024 · Background. Ferroptosis was first proposed by Dixon as a novel cell death in 2012 [].Unlike autophagy and apoptosis, ferroptosis is an iron-dependent and … WebMay 3, 2024 · Nontraditional forms of cell death, represented by ferroptosis and necroptosis, have been discovered in the field of kidney diseases, which have reshuffled …

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WebFeb 17, 2024 · Ferroptosis is a newly identified type of redox-driven cell death program 1,2.The regulatory metabolic cornerstones of the program include Fe-dependent generation of (phospho)lipid hydroperoxides ... WebSep 21, 2024 · Parkinson’s disease (PD) is a neurodegenerative disorder characterized by degeneration of dopaminergic neurons associated with dysregulation of iron homeostasis …

WebDec 29, 2024 · Ferroptosis is a newly identified type of programmed cell death, which preferentially targets iron-rich cancer cells such as hepatocellular carcinoma (HCC). … National Center for Biotechnology Information

WebThe expression of solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4) was increased, while prostaglandin-endoperoxide synthase 2 (Ptgs2) was decreased upon administration of Nano-taurine, suggesting that inhibiting ferroptosis may be involved in the mechanism during hepatic I/R injury. WebMar 31, 2024 · FTH silencing enhances ferroptosis induction by erastin and sorafenib in hepatoma cells . The pentapeptide protein Prominin2 promotes formation of …

WebAug 18, 2024 · Mechanically, ferritin heavy chain 1 (Fth), the ferroxidase function to oxidate redox-active Fe 2+ to redox-inactive Fe 3+, is likely responsible for the hypersensitivity of …

Web55 minutes ago · ROOT, Switzerland, April 14, 2024--Novocure (NASDAQ: NVCR) today announced 27 presentations on Tumor Treating Fields (TTFields) will be delivered at the American Association for Cancer Research ... heimo tuomolaWebAccordingly, we next determined whether a change in ferritin expression (FTH and mtFt) occurs during erastin-induced ferroptosis in HT22 neurons. FTH/mtFt levels were not … heimo savolainenWebHID-fed Fth Myh6/Myh6 Mice Have Cardiac Ferroptosis and Develop LV Hypertrophy. Differences in the heart-specific expression of Cre recombinases can lead to phenotypic differences in the resulting … heimo ojalaWebAlthough ferroptosis is an iron-dependent cell death mechanism involved in the development of some severe diseases (e.g., Parkinsonian syndrome, stroke and … heimo last alaskansWebMay 27, 2024 · To test whether there was a simultaneous degradation of FTH protein upon ferroptosis induction, we transfected plasmids containing GFP-FTH into HBE cells and monitored the level of ectopically expressed GFP-FTH. The results showed that HDM induced the degradation of GFP-FTH, which could be prevented by autophagy inhibitor … heimo seemannWebApr 30, 2024 · FTH suppression or deficiency increases sensitivity to ferroptosis, suggesting that ferritin may be involved in ferroptosis [30]. Our results show that the expression of FTH induced by HA was ... heimo tasanenWebFth-knockout mice were found to be more sensitive to ferroptosis following trauma, and the neuroprotection by melatonin was essentially canceled in Fth-knockout mice, which demonstrated neuroprotection of melatonin partly via preventing Fth-mediated neurons’ ferroptosis following TBI (Rui et al., 2024). heimo stamm